Dietary restriction of rodents decreases aging rate without affecting initial mortality rate - a meta-analysis
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چکیده
منابع مشابه
Dietary restriction of rodents decreases aging rate without affecting initial mortality rate -- a meta-analysis.
Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, whereas a change in aging rate will gradually lower mortality risk over time. Unrave...
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Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that re...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2013
ISSN: 1474-9718
DOI: 10.1111/acel.12061